DNA Demethylating Activity of Hydralazine in Cancer Cell Lines

نویسندگان

  • E de la Cruz-Hernandez
  • E Perez-Cardenas
  • L Taja-Chayeb
  • A Chavez-Blanco
چکیده

E de la Cruz-Hernandez, E Perez-Cardenas, L Taja-Chayeb, A Chavez-Blanco, C TrejoBecerril, J Trujillo, JL Medina-Franco, A Dueñas-Gonzalez* Unidad de Investigación en Cáncer, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, and Instituto Nacional de Cancerología, Mexico City, ISSEMYM Cancer Center, Toluca, Mexico. Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Gnidilatimonoein from Daphne mucronata inhibits DNA synthesis in human cancer cell lines

The anticancer agents from plant sources usually exert their action through a wide range of mechanisms. As part of our studies of plants for new anticancer agents with emphasis on Thymelaeaceae family, we examined the cytotoxicity and anti-tumor activity of the water extract of D. mucronata leaves against induced breast tumor in rats. In the current study, we were interested to obtain some know...

متن کامل

Gnidilatimonoein from Daphne mucronata inhibits DNA synthesis in human cancer cell lines

The anticancer agents from plant sources usually exert their action through a wide range of mechanisms. As part of our studies of plants for new anticancer agents with emphasis on Thymelaeaceae family, we examined the cytotoxicity and anti-tumor activity of the water extract of D. mucronata leaves against induced breast tumor in rats. In the current study, we were interested to obtain some know...

متن کامل

Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy.

PURPOSE The purpose of this study is to evaluate the demethylating and tumor suppressor-reactivating activity of hydralazine and procainamide. EXPERIMENTAL DESIGN MDA-231, MCF-7, and T24 cell lines were treated for 5 days with 10 micro M hydralazine or 10 micro M procainamide. 5-aza-deoxycytidine at 0.75 micro M was used as positive control. BALB/c nu/nu mice xenografted with MDA-231 cells we...

متن کامل

Advances in Brief Reactivation of Tumor Suppressor Genes by the Cardiovascular Drugs Hydralazine and Procainamide and Their Potential Use in Cancer Therapy

Purpose: The purpose of this study is to evaluate the demethylating and tumor suppressor-reactivating activity of hydralazine and procainamide. Experimental Design: MDA-231, MCF-7, and T24 cell lines were treated for 5 days with 10 M hydralazine or 10 M procainamide. 5-aza-deoxycytidine at 0.75 M was used as positive control. BALB/c nu/nu mice xenografted with MDA-231 cells were treated with th...

متن کامل

Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides

Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibitor with a DNA demethylating agent is a promising therapy to be tested. Here we report a mycosis f...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011